Figure 5
From: Thymidylate synthase as a determinant of pemetrexed sensitivity in non-small cell lung cancer
Effect of pemetrexed on the growth of TS-overexpressing NSCLC cells in vivo. Nude mice with tumour xenografts established by subcutaneous implantation of tumour fragments derived from the indicated NSCLC cell lines were treated with vehicle (control) or pemetrexed (100 mg kg−1, intraperitoneal) on days 1, 8, 15, and 22. Tumour volume was determined at the indicated times after the onset of treatment. Data are means±s.e.m. of values from eight mice per group. *P<0.05 for pemetrexed vs the corresponding value for vehicle (Student's two-tailed t-test).
