Table 1 Median inhibitory concentrations (μ M) for the antiproliferative effects of chemotherapeutic agents in TS-overexpressing NSCLC cells in vitro

From: Thymidylate synthase as a determinant of pemetrexed sensitivity in non-small cell lung cancer

Cell line

Pemetrexed

Cisplatin

Docetaxel

A549/Mock

0.07

2.62

0.12

A549/TS1

0.38

2.37

0.12

A549/TS2

0.44

2.21

0.13

H1299/Mock

0.08

2.93

0.32

H1299/TS1

0.22

2.98

0.30

H1299/TS2

0.22

2.90

0.30

PC9/Mock

0.03

0.72

0.18

PC9/TS1

0.11

0.72

0.18

PC9/TS2

0.10

0.65

0.17

  1. Abbreviations: NSCLC=non-small cell lung cancer; TS=thymidylate synthase.
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