Figure 3 | British Journal of Cancer

Figure 3

From: Immunohistochemical and molecular analyses of HER2 status in breast cancers are highly concordant and complementary approaches

Figure 3

Analysis of case A heterogeneity. (A) Schematic representation of case A with distinction of area 1 (HER2+) and area 2 (HER2−): H&E section, immunohistochemical stainings for HER2, ER, PR, CK5/6, CK8 and SISH evaluation of HER2 (magnification × 250). (B) Analysis of X-chromosome methylation pattern (HUMARA): allelic profiles for the total tumour and microdissected areas 1 and 2 are shown, before HpaII (upper line) and after HpaII (lower line) digestion. Differences between the two areas are represented by arrows.

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