Table 2 Univariate and multivariate logistic regression models for predictors of pCR following PST

From: An increase in cancer stem cell population after primary systemic therapy is a poor prognostic factor in breast cancer

Variables

Odds ratio

95% CI

P -value

Univariate analysis

 CD44+/CD24− tumour cell proportion (continuous)

1.014

0.996–1.034

0.135

 ALDH1 positivity (negative vs positive)

6.429

1.649–25.056

0.007

 Histologic grade (grades I, II vs III)

4.295

1.087–13.689

0.037

 Oestrogen receptor (ER+ vs ER−)

2.125

0.650–6.942

0.212

 Breast cancer subtype (non basal-like vs basal-like)

3.126

0.927–10.539

0.066

 cT stage (cT3, 4 vs cT1, 2)

3.419

0.879–13.367

0.077

 cN stage (cN1–3 vs cN0)

1.255

0.242–6.507

0.787

 PST regimen (AD vs AC)

2.118

0.636–7.051

0.221

Multivariate analysis

 ALDH1 positivity (negative vs positive)

4.150

0.970–17.765

0.055

 Histologic grade (grades I, II vs III)

2.625

0.670–10.276

0.166

  1. Abbreviations: AC=doxorubicin plus cyclophosphamide; AD=doxorubicin plus docetaxel; ALDH1=aldehyde dehydrogenase 1; CI=confidence interval; cN=clinical node; cT=clinical tumor; pCR=pathologic complete response; PST=primary systemic therapy.
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