Table 3 Multivariate analyses of overall survival and disease-free survival in patients with IHCC. (Cox proportional hazards model)
From: Prognostic significance of overexpression of c-Met oncoprotein in cholangiocarcinoma
| Â | Overall survival | Disease-free survival | ||||
|---|---|---|---|---|---|---|
| Â | HR | 95% CI | P -value | HR | 95% CI | P -value |
Macroscopic type | ||||||
 Mass forming | 4.572 | 1.440–14.516 | 0.0099 | 4.783 | 1.698–13.470 | 0.0030 |
 Non-mass forming | 1.00 |  |  | 1.00 |  |  |
Intrahepatic metastasis | ||||||
 Negative | 1.00 |  |  | 1.00 |  |  |
 Positive | 3.270 | 1.783–5.999 | 0.0001 | 2.781 | 1.604–4.822 | 0.0003 |
Invasion to portal vein | ||||||
 Negative | 1.00 |  |  | — |  |  |
 Positive | 0.881 | 0.388–1.999 | 0.7623 | — | — | — |
Lymph node metastasis | ||||||
 Negative | 1.00 |  |  | 1.00 |  |  |
 Positive | 1.998 | 1.110–3.597 | 0.0209 | 2.947 | 1.707–5.088 | 0.0001 |
Histopathological classification | ||||||
 Well differentiated | 1.00 |  |  | 1.00 |  |  |
 Moderately differentiated | 1.507 | 0.639–3.554 | 0.3491 | 0.753 | 0.345–1.642 | 0.4759 |
 Poorly differentiated | 2.031 | 0.526–7.835 | 0.3036 | 1.199 | 0.340–4.227 | 0.7772 |
Lymphatic vessel invasion | ||||||
 Negative | 1.00 |  |  | 1.00 |  |  |
 Positive | 3.119 | 0.851–11.435 | 0.0860 | 2.723 | 0.759–9.768 | 0.1243 |
Venous invasion | ||||||
 Negative | 1.00 |  |  | 1.00 |  |  |
 Positive | 3.121 | 0.825–11.807 | 0.0935 | 4.628 | 1.136–18.854 | 0.325 |
Perineural invasion | ||||||
 Negative | 1.00 |  |  | 1.00 |  |  |
 Positive | 0.588 | 0.265–1.305 | 0.1917 | 0.511 | 0.244–1.072 | 0.756 |
Bile duct margin | ||||||
 Negative | 1.00 |  |  | — |  |  |
 Positive | 1.871 | 0.902–3.882 | 0.0926 | — | — | — |
EGFR expression | ||||||
 Negative | 1.00 |  |  | 1.00 |  |  |
 Positive | 1.745 | 0.957–3.180 | 0.0690 | 1.987 | 1.125–3.511 | 0.0180 |
c-Met expression | ||||||
 Negative | 1.00 |  |  | 1.00 |  |  |
 Positive | 3.921 | 1.620–9.487 | 0.0003 | 3.502 | 1.562–7.851 | 0.0023 |
