Table 1 Characteristics of the included studies for normal breast epithelium, DCIS, DCIS-adjoining invasive breast cancer, MICB and invasive breast cancer

Study	Location	Number of samples included (n)	COX-2 positive (n)	COX-2 positive (%)
Normal breast
Cho et al (2006)	Korea	15	1	6.7
Zhao et al (2008)	USA	19	19	100.0
DCIS
Perrone et al (2005)	Italy	49	31	63.3
Cho et al (2006)	Korea	30	19	63.3
Kulkarni et al (2008)	USA	59	27	45.8
de la Torre et al (2010)	Spain	52	28	53.8
Kerlikowske et al (2010)	USA	279	124	44.4
DCIS-adjoining invasive breast cancer
Leo et al (2006)	Germany	29	16	55.2
MICB
de la Torre et al (2010)	Spain	40	30	74.0
Invasive breast cancer
Ristimaki et al (2002)	Finland	1576	589	37.4
Denkert et al (2003)	Germany	221	80	36.2
Spizzo et al (2003)	Austria	212	103	48.6
Wulfing et al (2003)	Germany	192	78	40.6
Witton et al (2004)	UK	179	38	21.2
Sivula et al (2005)	Finland	231	70	30.3
Surowiak et al (2005)	Poland	104	46	44.2
Gunnarsson et al (2006)	Sweden	284	108	38.0
Schmitz et al (2006)	Germany	113	49	43.4
Yamamoto et al (2008)	Japan	171	97	56.7
Zhao et al (2008)	USA	108	46	42.6
Darb-Esfahani et al (2009)	Germany	101	74	73.3

Abbreviations: COX2=cyclooxygenase 2; DCIS=ductal carcinoma in situ of breast; MCIB=microinvasive carcinoma of the breast.

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