Table 3 Association of known prostate cancer risk SNPs in the Ashkenazi Jewish population

From: Genetic architecture of prostate cancer in the Ashkenazi Jewish population

    

Unadjusted

Age adjusted

 

SNP

Chr.

Gene

Alleles (Maj/Min)

OR (95% CI)

P

OR (95% CI)

P

Power

rs721048

2

EHBP1

G/A

1.09 (0.93–1.27)

0.3

1.16 (0.94–1.44)

0.17

0.37

rs2660753

3

CHMP2B; POU1F1

C/T

1.04 (0.91–1.19)

0.55

0.98 (0.82–1.16)

0.78

0.65

rs9364554

6

SLC22A3; SLC22A2; LPAL2; LPA

C/T

1.1 (0.96–1.27)

0.19

1.01 (0.83–1.22)

0.94

0.54

rs10486567

7

JAZF1

G/A

0.98 (0.86–1.11)

0.71

1.14 (0.97–1.35)

0.12

1

rs6465657

7

LMTK2; BHLHB8

T/C

1.14 (1.01–1.27)

0.026

1.12 (0.96–1.3)

0.15

0.47

rs7008482

8

—

T/G

0.84 (0.74–0.94)

0.0036

0.87 (0.74–1.02)

0.08

1

rs1016343

8

—

C/T

1.24 (1.07–1.42)

0.0031

1.19 (0.98–1.43)

0.075

0.98

rs13254738

8

—

A/C

1.19 (1.06–1.33)

0.0039

1.15 (0.98–1.34)

0.086

0.42

rs16901979

8

—

C/A

1.01 (0.69–1.48)

0.94

0.94 (0.58–1.53)

0.8

0.77

rs6983267

8

—

G/T

0.81 (0.72–0.91)

0.00026

0.83 (0.72–0.97)

0.018

0.97

rs7000448

8

—

C/T

1.2 (1.07–1.34)

0.0021

1.18 (1.01–1.37)

0.033

0.61

rs4242382

8

—

G/A

1.31 (1.05–1.62)

0.015

1.63 (1.21–2.21)

0.0013

0.75

rs4242384

8

—

A/C

1.24 (0.92–1.68)

0.16

1.61 (1.09–2.36)

0.017

0.95

rs7920517

10

MSMB

G/A

0.92 (0.82–1.03)

0.17

0.84 (0.72–0.98)

0.026

0.92

rs10993994

10

MSMB

T/C

0.89 (0.79–1)

0.047

0.84 (0.72–0.98)

0.022

0.97

rs4962416

10

CTBP2

T/C

1 (0.89–1.13)

0.96

0.95 (0.81–1.11)

0.51

0.82

rs7931342

11

—

G/T

0.8 (0.7–0.9)

0.0003

0.79 (0.67–0.92)

0.0035

0.82

rs10896449

11

—

G/A

0.8 (0.71–0.91)

0.00044

0.8 (0.68–0.93)

0.0054

0.99

rs4430796

17

TCF2

G/A

1.17 (1.04–1.31)

0.0092

1.19 (1.02–1.39)

0.023

0.95

rs7501939

17

TCF2

C/T

0.9 (0.8–1.01)

0.065

0.95 (0.81–1.11)

0.53

0.89

rs1859962

17

—

G/T

0.89 (0.77–1.04)

0.14

0.92 (0.76–1.11)

0.4

0.83

rs2735839

19

KLK2; KLK3

G/A

0.91 (0.79–1.06)

0.24

0.89 (0.73–1.08)

0.24

0.73

rs5945572

X

NUDT11; NUDT10

G/A

1.3 (1.08–1.55)

0.0049

1.17 (0.92–1.48)

0.21

0.87

  1. Abbreviations: alleles=major/minor alleles; Chr.=chromosome; gene=nearby gene as reported in the cited literature; min=minor; maj=major; OR=odds ratio for the minor allele; SNP=single nucleotide polymorphism; 95% CI=95% confidence interval.
  2. SNPs in bold are significant at a nominal P<0.05 either without age adjustment, with age adjustment or both. Underlined P-values are significant at a false discovery rate of 5%.
Back to article page