Table 3 Univariate and multivariable Cox regression analysis of overall and disease-free survival in all neuroblastoma patients (n=226)
From: Expression of miR-487b and miR-410 encoded by 14q32.31 locus is a prognostic marker in neuroblastoma
Univariate analysis | Multivariable analysis with miR-487b | Multivariable analysis with miR-410 | ||||
|---|---|---|---|---|---|---|
Hazard ratio (95% CI) | P -value | Hazard ratio (95% CI) | P -value | Hazard ratio (95% CI) | P -value | |
Overall survival | ||||||
Age at diagnosis | ||||||
>18 months | 1.0 (reference) | <0.0001 | 1.0 (reference) | 0.0441 | 1.0 (reference) | 0.0258 |
<18 months | 0.247 (0.139–0.440) | 0.521 (0.276–0.983) | 0.485 (0.257–0.917) | |||
Stage | ||||||
4 | 1.0 (reference) | <0.0001 | 1.0 (reference) | 0.0001 | 1.0 (reference) | <0.0001 |
1, 2, 3, 4S | 0.160 (0.093–0.275) | 0.294 (0.158–0.547) | 0.279 (0.148–0.526) | |||
MYCN status | ||||||
Amplified | 1.0 (reference) | <0.0001 | 1.0 (reference) | 0.0704 | 1.0 (reference) | 0.0376 |
Non-amplified | 0.288 (0.171–0.487) | 0.601 (0.346–1.043) | 0.554 (0.318–0.967) | |||
MiR-487b expression | ||||||
High | 1.0 (reference) | 0.0001 | 1.0 (reference) | 0.0183 | ||
Low | 5.129 (2.218–11.861) | 2.833 (1.192–6.731) | ||||
MiR-410 expression | ||||||
High | 1.0 (reference) | 0.0034 | 1.0 (reference) | 0.2906 | ||
Low | 2.623 (1.375–5.003) | 1.448 (0.729–2.875) | ||||
Disease-free survival | ||||||
Age at diagnosis | ||||||
>18 months | 1.0 (reference) | 0.0002 | 1.0 (reference) | 0.1678 | 1.0 (reference) | 0.0990 |
<18 months | 0.429 (0.274–0.672) | 0.703 (0.427–1.160) | 0.656 (0.397–1.083) | |||
Stage | ||||||
4 | 1.0 (reference) | <0.0001 | 1.0 (reference) | 0.0014 | 1.0 (reference) | 0.0016 |
1, 2, 3, 4S | 0.307 (0.200–0.470) | 0.445 (0.270–0.731) | 0.443 (0.268–0.735) | |||
MYCN status | ||||||
Amplified | 1.0 (reference) | 0.0016 | 1.0 (reference) | 0.3112 | 1.0 (reference) | 0.2479 |
Non-amplified | 0.449 (0.273–0.738) | 0.762 (0.450–1.290) | 0.733 (0.432–1.242) | |||
MiR-487b expression | ||||||
High | 1.0 (reference) | 0.0002 | 1.0 (reference) | 0.0144 | ||
Low | 3.036 (1.686–5.466) | 2.145 (1.164–3.952) | ||||
MiR-410 expression | ||||||
High | 1.0 (reference) | 0.0026 | 1.0 (reference) | 0.0912 | ||
Low | 2.253 (1.328–3.820) | 1.614 (0.926–2.813) | ||||
