Figure 6
Representative sections of early invasive oral carcinoma (IOC) taken from patient biopsies (A–E) and a tissue-engineered invasive carcinoma (TEIOC) (F–J). TEIOC were generated by culturing OSCC (Cal27) and normal oral fibroblasts on DED at an air/liquid interface for 21 days. Sections have been stained with H&E (A and F) and immunohistochemically stained to show the pattern of expression of Ki67 (B and G), AE1/3 (C and H), collagen type IV (Col IV; D and I) and integrin αvβ6 (E and J) and counterstained with haematoxylin. Scale bar indicates 200 μm.
