Figure 1

Hierarchical clustering of 13-gene microRNA signature. (A) Signature miRNA clustered by expression values and sample (lung cell lines) using GenePattern (Broad Institute) (B) Signature miRNA clustered by expression and sample (lung and colorectal tumours). Samples A–D are primary lung tumours (P) from patients treated with erlotinib. Samples U38–U40 are metastatic lung tumours (M) from patients treated with erlotinib and U41 is a metastatic colorectal tumour from a patient treated with the EGFR inhibitor, cetuximab.