Figure 4 | British Journal of Cancer

Figure 4

From: The cyclin-dependent kinase inhibitor p57Kip2 is epigenetically regulated in carboplatin resistance and results in collateral sensitivity to the CDK inhibitor seliciclib in ovarian cancer

Figure 4

(A) Methylation specific PCR analysis for PEO1 and PEO1CarbR lines in the absence or presence of azacytidine (+aza) for the unmethylated portion (U) and for the methylated portion (M). Results shown are typical for those obtained in replicate experiments (n=4). (B) Pyrosequencing for detection and quantitation of methylation in the promoter region of the p57Kip2 gene with extent of methylation obtained from pyrosequencing analysis shown on the y-axis. Black bar indicates the parental PEO1 line; white bar indicates PEO1CarbR carboplatin resistant line.

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