Table 1 PTEN and clinicopathological parameters

From: Loss of PTEN is associated with elevated EGFR and HER2 expression and worse prognosis in salivary gland cancer

 

PTEN FISH

PTEN IHC

Parameter

Non-deleted

Hemizygous

Homozygous

Pos

Neg

Total

180 (77.5%)

35 (15.1%)

17 (7.3%)

214 (78.4%)

59 (21.6%)

ACCC

30 (85.7%)

5 (14.3%)

0

36 (90.0%)

4 (10.0%)

ADCC

41 (97.6%)

1 (2.4%)

0

42 (84.0%)

8 (16.0%)

MEC

35 (89.7%)

3 (7.7%)

1 (2.6%)

36 (85.7%)

6 (14.3%)

SDC

8 (33.3%)

9 (37.5%)

7 (29.2%)

14 (58.3%)

10 (41.7%)

ACNOS

11 (50.0%)

5 (22.7%)

6 (27.3%)

19 (70.4%)

8 (29.6%)

SQCC

15 (57.7%)

9 (34.6%)

2 (7.7%)

17 (63.0%)

10 (37.0%)

MYEC

15 (83.3%)

2 (11.1%)

1 (5.6%)

19 (95.0%)

1 (5.0%)

Others

25 (13.9%)

1 (2.7%)

0

31 (72.1%)

12 (27.9%)

Age

 <70

108 (82.4%)

15 (11.5%)

8 (6.1%)

140 (84.3%)

26 (15.7%)

 >70

48 (68.6%)

14 (20.0%)

8 (11.4%)

74 (69.2%)

33 (30.8%)**

Grade

 Low/intermediate

112 (88.2%)

14 (11.0%)

1 (0.8%)

131 (86.8%)

20 (13.2%)

 High

68 (64.8%)

21 (20.0%)

16 (15.2%)***

83 (68.0%)

39 (32.0%)***

T-stage

 T1–T2

103 (79.2%)

19 (14.6%)

8 (6.2%)

130 (82.8%)

27 (17.2%)

 T3–T4

73 (74.5%)

16 (16.3%)

9 (9.2%)

80 (71.4%)

32 (28.6%)*

N-stage

 N0

134 (85.4%)

16 (10.2%)

7 (4.5%)

152 (82.6%)

32 (17.4%)

 N1–3

39 (57.4%)

19 (27.9%)

10 (14.7%)***

55 (67.1%)

27 (32.9%)**

EGFR FISH

 No CNG

131 (82.9%)

21 (13.3%)

6 (3.8%)

153 (83.6%)

30 (16.4%)

 CNG

12 (40.0%)

8 (26.7%)

10 (33.3%)***

18 (54.5%)

15 (45.5%)***

EGFR IHC

 0+,1+,2+

123 (80.4%)

20 (13.1%)

10 (6.5%)

153 (81.4%)

35 (18.6%)

 3+

27 (64.3%)

9 (21.4%)

6 (14.3%)*

35 (71.4%)

14 (28.6%)

HER2 FISH

 No amplification

148 (80.0%)

27 (14.6%)

10 (5.4%)

171 (79.9%)

43 (20.1%)

 Amplification

4 (36.4%)

1 (9.1%)

6 (54.5%)***

7 (63.6%)

4 (36.4%)

HER2 IHC

 0, 1+, 2+

145 (81.9%)

23 (13.0%)

9 (5.1%)

179 (82.5%)

38 (17.5%)

 3+

5 (27.8%)

6 (33.3%)

7 (38.9%)***

9 (47.4%)

10 (52.6%)***

  1. Abbreviations: ACC=adenoid cystic carcinoma; ACNOS=adenocarcinoma NOS; CNG=copy number gain; EGFR=epidermal growth factor receptor; FISH=fluorescence in situ hybridisation; HER2=human epidermal growth factor receptor 2; IHC=immunohistochemistry; MEC=mucoepidermoid carcinoma; MYEC=myoepithelial carcinoma; Neg=negative; Pos=positive; PTEN=phosphatase and tensin homologue located on chromosome 10; SDC=salivary duct carcinoma; SQCC=squamous cell carcinoma.
  2. *P⩽0.05, **P⩽0.01, ***P⩽0.001. Statistically significant associations are highlighted in bold.
Back to article page