Table 3 Interrelationships between different pathological and clinical parameters in patients selected for potentially curative resection for oesophageal adenocarcinoma (n=98)
Sex | mGPS | TNM stage | Tumour differentiation | Resection margin | LNR | Klintrup– Makinen score | Necrosis score | CD8 tertiles | CD68 tertiles | Ki67 tertiles | CD34 tertiles | Neo-adjuvant therapy | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Age in years (<65/65–74/⩾75 years) | 0.199 | 0.248 | 0.688 | 0.939 | 0.991 | 0.586 | 0.977 | 0.505 | 0.510 | 0.749 | 0.110 | 0.923 | 0.639 |
Sex (male/female) | 0.155 | 0.605 | 0.008 | 1.00 | 0.170 | 0.302 | 0.091 | 0.609 | 0.203 | 0.813 | 0.693 | 0.400 | |
mGPS | 0.823 | 0.616 | 0.569 | 0.328 | 0.894 | 0.228 | 0.243 | 0.838 | 0.311 | 0.723 | 0.988 | ||
TNM stage (I/II/III) | 0.008 | <0.001 | <0.001 | 0.403 | 0.754 | 0.203 | 0.593 | 0.430 | 0.081 | 0.420 | |||
Tumour differentiation (well-mod/poor) | 1.00 | <0.001 | 0.322 | 0.012 | 0.422 | 0.024 | 0.655 | 0.922 | 0.838 | ||||
Resection margin (R0/R1) | 0.004 | 0.144 | 0.344 | 0.004 | 0.362 | 0.307 | 0.719 | 0.242 | |||||
LNR | 0.009 | 0.388 | 0.093 | 0.332 | 0.293 | 0.168 | 0.417 | ||||||
Klintrup–Makinen score (low/igh grade) | 1.00 | 0.002 | 0.078 | 0.105 | 0.813 | 1.00 | |||||||
Necrosis score (low/high grade) | 0.219 | 0.724 | 0.140 | 0.109 | 0.839 | ||||||||
CD8 tertiles | 0.002 | 0.051 | 0.044 | 0.016 | |||||||||
CD68 tertiles | <0.001 | 0.994 | 0.004 | ||||||||||
Ki67 tertiles | 0.050 | <0.001 | |||||||||||
CD34 | 0.261 |