Table 5 Relationships between clinico-pathological factors and survival, in patients selected for potentially curative resection for oesophageal adenocarcinoma without neo-adjuvant therapy (n=53)
Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
Hazard ratio (95% CI) | P -value | Hazard ratio (95% CI) | P -value | |
Patient-related factors | ||||
Age (<65/65 –74/⩾75 years) | 2.07 (1.13–3.77) | 0.018 | 2.62 (1.27–5.39) | 0.009 |
Sex (male/female) | 0.77 (0.27–2.21) | 0.625 | ||
mGPS (0/1/2) | 4.14 (1.80–9.51) | 0.001 | 12.71 (4.15–38.94) | <0.001 |
Tumour-related factors | ||||
TNM stage (I/II/III) | 2.46 (1.34–4.49) | 0.004 | 0.246 | |
Tumour differentiation (well-mod/poor) | 2.35 (1.13–4.92) | 0.023 | 0.552 | |
Resection margin (R0/R1) | 2.13 (1.02–4.49) | 0.046 | 0.607 | |
Positive to total lymph node ratio (0/⩽0.2/>0.2) | 2.45 (1.55–3.89) | <0.001 | 3.18 (1.77–5.72) | <0.001 |
Adjuvant therapy (no/yes) | 2.45 (0.83–7.22) | 0.105 | ||
Klintrup–Makinen score (low/high grade) | 0.28 (0.08–0.92) | 0.036 | 0.055 | |
Necrosis score (low/high grade) | 1.29 (0.61–2.70) | 0.505 | ||
CD8 tertiles | 0.68 (0.43–1.10) | 0.117 | ||
CD68 tertiles | 1.49 (0.97–2.28) | 0.066 | 1.88 (1.12–3.15) | 0.017 |
Ki67 tertiles | 1.35 (0.78–2.35) | 0.289 | ||
CD34 tertiles | 0.73 (0.45–1.20) | 0.214 | ||
