Table 2 Diagnostic performance of gFOBT, iFOBT and blood-based inflammatory markers: sensitivities and specificities for detection of advanced adenoma and colorectal cancer (CRC)

From: Comparison and combination of blood-based inflammatory markers with faecal occult blood tests for non-invasive colorectal cancer screening

  

Sensitivity % (95% CI)

 

Test

Cut point (ng ml −1)

Advanced adenoma ( n =183)

CRC ( n =67)

Specificity % (95% CI)

gFOBT

—

7.7 (4.6–12.4)

40.3 (29.4–52.3)

97.7 (94.7–99.0)

CRP

2499.9

4.9 (2.6–9.1)

19.4 (11.7–30.4)

90.3 (85.7–93.6)

sCD26

133.5

4.4 (2.2–8.4)

0 (0–5.4)

97.2 (94.1–98.7)

TIMP-1

928.2

7.1 (4.2–11.8)

13.4 (7.2–26.6)

97.7 (94.7–99.0)

iFOBT

24.0a

19.7 (14.6–26.0)

65.7 (53.7–75.9)

97.7 (94.7–99.0)

  1. Abbreviations: CI=confidence interval; CRP=C-reactive protein; gFOBT=guaiac-based faecal occult blood test; iFOBT=immunochemical faecal occult blood test; sCD26=serum CD26; TIMP-1=tissue inhibitor of metalloproteinases 1.
  2. μg per gram stool.
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