Figure 1

H&E stain showing the difference between the two additional prognostic parameters – tumour budding and tumour-budding configuration in CRC. (A) Infiltrating tumour-border configuration and presence of many tumour buds at the invasive front. (B) Infiltrating tumour-border configuration without tumour buds; in this case, the invasive front includes only tumour glands. (C) Pushing tumour-border configuration and presence of several tumour buds and (D) pushing tumour-border configuration without tumour budding.