Table 4 Stratified analyses by mould-active agent
Outcome | Trials (patients) | RR a (95% CI) | P- value | P- value for interaction test |
|---|---|---|---|---|
Mould-active agent | ||||
Proven or probable IFI | 0.1 | |||
Amphotericin | 3 (287) | 1.46 (0.70, 3.05) | 0.31 | |
Other azoles | 12 (3426) | 0.60 (0.43, 0.84) | 0.003 | |
Echinocandin | 3 (1089) | 0.71 (0.29, 1.73) | 0.45 | |
Invasive aspergillosis | 0.29 | |||
Amphotericin | 3 (618) | 1.18 (0.28, 4.97) | 0.82 | |
Other azoles | 9 (2796) | 0.52 (0.36, 0.76) | 0.0006 | |
Echinocandin | 3 (1089) | 0.19 (0.03, 1.11) | 0.07 | |
IFI-related mortality | ||||
Amphotericin | 4 (642) | 0.91 (0.39, 2.16) | 0.83 | |
Other azoles | 9 (2648) | 0.64 (0.38, 1.08) | 0.09 | |
Echinocandin | 2 (982) | 0.70 (0.12, 4.28) | 0.70 | |
IA-related mortality | 0.43 | |||
Amphotericin | 2 (101) | 3.41 (0.14, 81.07) | 0.45 | |
Other azoles | 5 (1531) | 0.63 (0.18, 2.13) | 0.46 | |
Echinocandin | 2 (982) | 0.27 (0.03, 2.38) | 0.24 | |
Overall mortality | 0.79 | |||
Amphotericin | 3 (618) | 1.11 (0.78, 1.59) | 0.55 | |
Other azoles | 11 (3270) | 0.99 (0.86, 1.14) | 0.89 | |
Echinocandin | 2 (982) | 0.89 (0.42, 1.88) | 0.76 | |
AEs requiring antifungal treatment discontinuation or modification | 0.001 | |||
Amphotericin | 4 (642) | 5.98 (1.20, 29.86) | 0.03 | |
Other azoles | 10 (2869) | 1.92 (1.19, 3.08) | 0.007 | |
Echinocandin | 2 (982) | 0.59 (0.34, 1.03) | 0.06 | |
