Table a1 Search strategies used to identify randomised study of mould-active vs fluconazole antifungal prophylaxis in patients with cancer or undergoing haematopoietic stem cell transplantation

From: Mould-active compared with fluconazole prophylaxis to prevent invasive fungal diseases in cancer patients receiving chemotherapy or haematopoietic stem-cell transplantation: a systematic review and meta-analysis of randomised controlled trials

#

Searches

Results

Ovid MEDLINE(R) 1948 to August (week 2) 2011 (run on August 24, 2011)

1

Fluconazole/ or (fluconazol* or flucolich or arnazole or beagyne or elazor or flucobeta or solacap or diflucan or triflucan or ‘uk 49858’ or uk49858 or neofomiral or lavisa or zonal or ‘fluc hexal’ or fluchexal or oxifungol or fungata or loitin or flunazul or zoltrix).mp.

13 405

2

exp Aspergillus/pc or (exp Aspergillus/ and (prophyla* or prevent*).mp.) or exp Mycoses/pc or (exp Mycoses/ and (prophyla* or prevent*).mp.) or (prophylaxis or (prevent* adj2 (fungal or fungus))).ti,ab.

64 991

3

Stem Cell Transplantation.mp. or exp Stem Cell Transplantation/

45 185

4

exp neoplasms/ or (cancer or oncolog*).mp.

2 389 250

5

exp Neutropenia/ or neutropeni*.mp.

28 301

6

3 or 4 or 5

2 426 526

7

1 and 2 and 6

473

8

randomised controlled trial.pt.

314 177

9

controlled clinical trial.pt.

83 186

10

randomised.ab.

220 043

11

drug therapy.fs.

1 486 777

12

randomly.ab.

158 898

13

trial.ab.

227 567

14

groups.ab.

1 054 838

15

8 or 9 or 10 or 11 or 12 or 13 or 14

2 740 074

16

exp animals/ not humans.sh.

3 651 958

17

15 not 16

2 325 347

18

7 and 17

343

Database: EMBASE <1980 to 2011 Week 33> (run on 24 August 2011)

1

fluconazole/ or (fluconazol* or flucolich or arnazole or beagyne or elazor or flucobeta or solacap or diflucan or triflucan or ‘uk 49858’ or uk49858 or neofomiral or lavisa or zonal or ‘fluc hexal’ or fluchexal or oxifungol or fungata or loitin or flunazul or zoltrix or Afungil or Alflucoz or Baten or Biocanol or Biozolene or CCRIS 7211 or Canzol or Cryptal or DRG-0005 or Dimycon or Elazor or Mutum or Pritenzol or Syscan or Triconal or Zemyc or Zoltec).mp.

29 035

2

(exp Aspergillus/ and (prevent* or prophyla*)).mp. or exp mycosis/pc or (exp mycosis/ and (prevent* or prophyla*)).mp. or ((exp Aspergillus/ or exp mycosis/) and (prophylaxis/ or infection prevention/))

16 911

3

stem cell transplantation.mp. or exp stem cell transplantation/

59 342

4

exp neoplasms/ or (cancer or oncolog*).mp.

2 848 209

5

exp NEUTROPENIA/ or exp FEBRILE NEUTROPENIA/ or neutropenia.mp.

61 135

6

3 or 4

2 876 781

7

1 and 2 and 6

1655

8

randomised controlled trial/ or ct.fs. or random$.mp. or doubl$adj blind$.mp.

996 967

9

7 and 8

554

EBM Reviews—Cochrane Central Register of Controlled Trials, 3rd Quarter 2011 (run on 24 August 2011)

1

fluconazole/ or (fluconazol* or flucolich or arnazole or beagyne or elazor or flucobeta or solacap or diflucan or triflucan or ‘uk 49858’ or uk49858 or neofomiral or lavisa or zonal or ‘fluc hexal’ or fluchexal or oxifungol or fungata or loitin or flunazul or zoltrix or Afungil or Alflucoz or Baten or Biocanol or Biozolene or CCRIS 7211 or Canzol or Cryptal or DRG-0005 or Dimycon or Elazor or Mutum or Pritenzol or Syscan or Triconal or Zemyc or Zoltec).mp.

668

2

exp Aspergillus/pc or (exp Aspergillus/ and (prophyla* or prevent*).mp.) or exp Mycoses/pc or (exp Mycoses/ and (prophyla* or prevent*).mp.) or (prophylaxis or (prevent* adj2 (fungal or fungus))).ti,ab.

10 404

3

Stem Cell Transplantation.mp. or exp Stem Cell Transplantation/ or exp Bone Marrow Transplantation/

2679

4

exp neoplasms/ or (cancer or oncolog*).mp.

56 297

5

neutropenia.mp. or exp Neutropenia/

3010

6

3 or 4 or 5

58 299

7

1 and 2 and 6

104