Table a3 Stratified analyses by study population and fluconazole dose

From: Mould-active compared with fluconazole prophylaxis to prevent invasive fungal diseases in cancer patients receiving chemotherapy or haematopoietic stem-cell transplantation: a systematic review and meta-analysis of randomised controlled trials

Outcome

Trials (patients)

RR* (95% CI)

P- value

P- value for interaction test

Study population

 Proven or probable IFI

   

0.82

HSCT

9 (2415)

0.70 (0.49, 0.99)

0.004

 

Chemotherapy

4 (1259)

0.59 (0.15, 2.27)

0.45

 

 Invasive aspergillosis

   

0.73

HSCT

8 (2619)

0.47 (0.29, 0.75)

0.002

 

Chemotherapy

3 (780)

0.60 (0.16, 2.28)

0.45

 

 IFI-related mortality

   

0.96

HSCT

8 (2097)

0.81 (0.50, 1.31)

0.39

 

Chemotherapy

2 (571)

0.78 (0.17, 3.46)

0.74

 

 IA-related mortality

   

0.23

HSCT

4 (1065)

0.27 (0.03, 2.38)

0.24

 

Chemotherapy

2 (571)

1.69 (0.21, 13.59)

0.62

 

 Overall Mortality

   

0.42

HSCT

9 (2697)

1.06 (0.90, 1.25)

0.50

 

Chemotherapy

2 (571)

0.86 (0.54, 1.38)

0.54

 

 AEs requiring antifungal treatment discontinuation or modification

   

0.43

HSCT

8 (2111)

2.14 (0.94, 4.87)

0.07

 

Chemotherapy

3 (780)

1.51 (1.16, 1.98)

0.0003

 

Fluconazole dose

 Proven or probable IFI

   

0.18

Fluconazole ⩾400 mg per day

12 (4044)

0.65 (0.46, 0.93)

0.02

 

Fluconazole <400 mg per day

6 (758)

1.07 (0.57, 2.00)

0.84

 

 Invasive aspergillosis

   

0.11

Fluconazole ⩾400 mg per day

11 (3847)

0.49 (0.34, 0.70)

0.0001

 

Fluconazole <400 mg per day

4 (656)

1.42 (0.41, 4.93)

0.59

 

 IFI-related mortality

   

0.14

Fluconazole ⩾400 mg per day

9 (3142)

0.57 (0.38, 0.86)

0.007

 

Fluconazole <400 mg per day

6 (1130)

1.22 (0.49, 3.02)

0.67

 

 IA-related mortality

   

0.87

Fluconazole ⩾400 mg per day

5 (1748)

0.51 (0.13, 1.95)

0.32

 

Fluconazole <400 mg per day

4 (866)

0.63 (0.07, 6.09)

0.69

 

 Overall mortality

   

0.87

Fluconazole ⩾400 mg per day

10 (3740)

0.98 (0.85, 1.12)

0.76

 

Fluconazole <400 mg per day

6 (1130)

1.03 (0.57, 1.88)

0.92

 

 AEs requiring antifungal treatment discontinuation or modification

   

0.03

Fluconazole ⩾400 mg per day

10 (3213)

1.49 (0.91, 2.43)

0.12

 

Fluconazole <400 mg per day

6 (1280)

3.19 (2.01, 5.05)

0.0001

 
  1. Abbreviations: AEs=adverse events; CI=confidence interval; HSCT=haematopoietic stem cell transplantation; IA=invasive aspergillosis; IFI=invasive fungal infection; ITT=intention-to-treat; RR=relative risk. *RR<1 represents an advantage of mould-active coverage compared with fluconazole using a random-effects model.
Back to article page