Table 2 Correlation (95% CI) between inflammatory markers and selected covariates in control participants^a

Covariate	CRP	IL-6	sTNF-R1	sTNF-R2
IL-6	0.44 (0.35–0.53)
sTNF-R1	0.29 (0.18–0.39)	0.33 (0.22–0.42)
sTNF-R2	0.27 (0.16–0.37)	0.23 (0.12–0.33)	0.65 (0.58–0.71)
BMI	0.40 (0.30–0.49)	0.29 (0.18–0.39)	0.17 (0.06–0.28)	0.05 (−0.06 to 0.16)
Waist	0.32 (0.22–0.42)	0.31 (0.20–0.41)	0.21 (0.10–0.31)	0.10 (−0.01 to 0.21)
WHR	0.23 (0.13–0.34)	0.25 (0.14–0.35)	0.16 (0.04–0.26)	0.09 (−0.03 to 0.20)
HbA1c	0.16 (0.05–0.27)	0.09 (−0.02 to 0.20)	0.10 (−0.01 to 0.21)	0.01 (−0.10 to 0.12)
Diabetes^b	1.37 (1.08–1.74)	1.49 (1.06–2.11)	1.41 (0.44–4.55)	1.30 (0.42–4.02)
Smoking^c	1.30 (1.10–1.54)	1.36 (1.06–1.74)	1.60 (0.72–3.58)	0.97 (0.43–2.16)
Sex^d	1.07 (0.95–1.21)	1.21 (1.02–1.44)	1.79 (0.97–3.31)	0.90 (0.50–1.62)
Age^e	0.13 (0.03–0.23)	0.18 (0.08–0.28)	0.30 (0.20–0.39)	0.32 (0.22–0.41)

Abbreviations: CRP=C-reactive protein; IL-6=interleukin-6; sTNF-R1 and sTNF-R2=soluble tumour necrosis factor receptors 1 and 2; BMI=body mass index; waist=waist circumference; WHR=waist–hip ratio; HbA1c=glycated haemoglobin; age=age at recruitment.
^aFor continuous covariates, Spearman’s partial rank correlation coefficients were applied. For categorical covariates we used logistic regression. Both methods were performed in controls and adjusted for age, sex, and EPIC recruitment centre if not stated otherwise.
^bDiabetic (HbA1c ⩾6.5% or self-reported diabetes at baseline) vs non-diabetic participants.
^cCurrent vs never smokers.
^dMen vs women, adjusted for age and EPIC recruitment centre.
Adjusted for sex and EPIC recruitment centre.

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