Table 3 Mutational status of KRAS and other genes
From: KRAS mutations in primary tumours and post-FOLFOX metastatic lesions in cases of colorectal cancer
Case | Primary site | Mutation status | Pre-FOLFOX metastatic site | Mutation status | Post-FOLFOX recurrence site | Mutation status |
|---|---|---|---|---|---|---|
1 | Rectum | KRAS G12D | — | — | Liver | KRAS G12D |
2 | Colon | KRAS G12D | Liver | KRAS G12D | Liver | KRAS G12D |
3 | Colon | KRAS G12D | Liver | KRAS G12D | Liver | KRAS G12D |
4 | Rectum | KRAS G12R | Local recurrence | KRAS G12R | Local recurrence | KRAS G12R |
5 | Rectum | KRAS G12D | — | — | Lung | KRAS G12D |
6 | Colon | WT | — | — | LN | WT |
7 | Rectum | KRAS G12S | Liver | KRAS G12S | Lung | KRAS G12S |
| Â | Â | Â | Lung | KRAS G12S | Â | Â |
8 | Rectum | WT | — | — | Lung | WT |
9 | Colon | WT | — | — | Liver | WT |
10 | Colon | KRAS G12A | Liver | KRAS G12A | Lung | KRAS G12A |
| Â | Â | Â | Liver | KRAS G12A | Lung | KRAS G12A |
| Â | Â | Â | Lung | WT | Â | Â |
11 | Colon | KRAS G13D | Lung | KRAS G13D | Lung | KRAS G13D |
12 | Rectum | KRAS A146V | Liver | KRAS A146V | Liver | KRAS A146V |
13 | Rectum | KRAS G12V | Liver | KRAS G12V | Liver | KRAS G12V |
| Â | Â | Â | Lung | KRAS G12V | Â | Â |
14 | Rectum | KRAS G12D | Subcutaneous | KRAS G12D | Lung | KRAS G12D |
15 | Colon | WT | — | — | Local recurrence | WT |
16 | Rectum | KRAS G12S, PIK3CA E542K | Liver | KRAS G12S, PIK3CA E542K | Lung | KRAS G12S, PIK3CA E542K |
17 | Rectum | KRAS G12D | Lung | KRAS G12D | Lung | KRAS G12D |
18 | Colon | KRAS G12D | Liver | KRAS G12D | Lung | KRAS G12D |
| Â | Â | Â | Â | Â | Lung | KRAS G12D |
19 | Rectum | NRAS Q61H | Liver | NRAS Q61H | Lung | NRAS Q61H |
20 | Rectum | PIK3CA E542K | — | — | Local recurrence | PIK3CA E542K |
21 | Rectum | KRAS A146V | Liver | KRAS A146V | Lung | KRAS A146V |
| Â | Â | Â | Â | Â | Lung | KRAS A146V |
