Table 3 OR and 95% CI for association among parity, age at first birth, and risk of EA or/and EJA, SCC of the oesophagus in women and men aged equal or older than 50 years, Sweden, 1932–2008

From: Reproductive factors and risk of oesophageal cancer, a population-based nested case–control study in Sweden

 

EA

EJA

EA and EJA

SCC of the oesophagus

 

⩾50

⩾50

⩾50

⩾50

 

OR (95% CI)

OR (95% CI)

OR (95% CI)

OR (95% CI)

Women

 Paritya,b

Non-parous

1.00 (Reference)

1.00 (Reference)

1.00 (Reference)

1.00 (Reference)

Parous

0.66 (0.37–1.17)

0.69 (0.45–1.06)

0.67 (0.47–0.94)

0.68 (0.50–0.94)

 Number of childrena,c

1

1.00 (Reference)

1.00 (Reference)

1.00 (Reference)

1.00 (Reference)

2

0.81 (0.45–1.49)

0.75 (0.47–1.20)

0.77 (0.53–1.11)

0.53 (0.38–0.75)

⩾3

0.72 (0.38–1.38)

1.21 (0.75–1.96)

1.01 (0.69–1.49)

0.68 (0.48–0.98)

P-value for trend

0.30

0.26

0.80

0.19

 Age at first birth (years)a,c

<20

1.00 (Reference)

1.00 (Reference)

1.00 (Reference)

1.00 (Reference)

20–29

1.11 (0.60–2.03)

0.83 (0.53–1.30)

0.94 (0.66–1.35)

0.99 (0.69–1.40)

⩾30

1.01 (0.39–2.65)

0.80 (0.41–1.60)

0.89 (0.51–1.55)

0.54 (0.29–1.00)

P-value for trend

0.90

0.37

0.53

0.10

Men

 Paritya,b

No children

1.00 (Reference)

1.00 (Reference)

1.00 (Reference)

1.00 (Reference)

Has children

0.77 (0.64–0.93)

0.92 (0.76–1.10)

0.84 (0.74–0.96)

0.61 (0.52–0.72)

 Number of childrena,c

1

1.00 (Reference)

1.00 (Reference)

1.00 (Reference)

1.00 (Reference)

2

1.05 (0.83–1.32)

1.10 (0.89–1.36)

1.07 (0.92–1.25)

0.99 (0.78–1.24)

⩾3

0.99 (0.78–1.27)

1.09 (0.86–1.37)

1.04 (0.88–1.23)

0.91 (0.71–1.17)

P-value for trend

0.96

0.78

0.86

0.24

 Age at first birth (years)a,c

<20

1.00 (Reference)

1.00 (Reference)

1.00 (Reference)

1.00 (Reference)

20–29

0.65 (0.45–0.95)

0.76 (0.53–1.10)

0.71 (0.55–0.92)

0.66 (0.46–0.93)

⩾30

0.66 (0.44–1.00)

0.57 (0.38–0.85)

0.61 (0.46–0.82)

0.55 (0.37–0.82)

P-value for trend

0.48

0.01

<0.01

0.01

  1. Abbreviations: CI=confidence interval; EA=oesophageal adenocarcinoma; EJA=gastroesophageal junctional adenocarcinoma; OR=odds ratio; SCC=squamous cell carcinoma.
  2. aORs were estimated from conditional logistic regression models, conditioned on age and sex, and adjusted for education, diabetes, obesity, tobacco smoking, and alcohol abuse, and when appropriate for parity and age at first birth.
  3. b‘Non-parous’ labelled women without children and ‘parous’ labelled women with children. The variable had the same categories for men but was named as ‘no children’ and ‘has children’.
  4. cMen or women have children.
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