Table 3 Gastric atrophy defined by other serology criteria in literature and its association with OSCC risk

From: Gastric atrophy and oesophageal squamous cell carcinoma: possible interaction with dental health and oral hygiene habit

 

Controls, N (%)

Cases, N (%)

Adjusted OR (95% CI) a

PGI

 PGI ⩾30

500 (95.4)

274 (93.5)

Referent

 PGI <30

24 (4.6)

19 (6.5)

1.52 (0.79–2.93)

Stratifying by PGII level b

 PGI ⩾30 and PGII<11.8

226 (43.1)

97 (33.1)

Referent

 PGI <30 and PGII <11.8

4 (0.8)

3 (1.0)

1.94 (0.91–4.13)

 PGI ⩾30 and PGII ⩾11.8

274 (52.3)

176 (60.4)

Referent

 PGI <30 and PGII ⩾11.8

20 (3.8)

16 (5.5)

1.10 (0.23–5.17)

PGI/PGII ratio b

 Ratio ⩾3

490 (93.5)

265 (90.8)

Referent

 Ratio <3

34 (6.5)

27 (9.2)

1.50 (0.85–2.60)

Stratifying by PGII level b

 Ratio ⩾3 and PGII <11.8

233 (44.5)

100 (34.1)

Referent

 Ratio <3 and PGII <11.8

21 (4.0)

14 (4.8)

2.32 (1.00–5.39)

 Ratio ⩾3 and PGII ⩾11.8

257 (49.0)

165 (56.7)

Referent

 Ratio<30 and PGII ⩾11.8

13 (2.5)

13 (4.4)

1.03 (0.49–2.20)

PGI and PGI/PGII ratio b

 PGI ⩾70 or ratio ⩾3

497 (94.9)

267 (91.5)

Referent

 PGI <70 and ratio <3

27 (5.1)

25 (8.5)

1.69 (0.93–3.10)

Stratifying by PGII level b

 (PGI ⩾70 or ratio ⩾3) and PGII <11.8

233 (44.5)

100 (34.19)

Referent

 (PGI <70 and ratio <3) and PGII <11.8

14 (2.6)

12 (4.1)

2.31 (0.99–5.38)

 (PGI ⩾70 or ratio ⩾3) and PGII ⩾11.8

264 (50.4)

167 (57.4)

Referent

 (PGI <70 and ratio <3) and PGII ⩾11.8

13 (2.5)

13 (4.4)

1.24 (0.52–2.94)

  1. Abbreviations: CI=confidence interval; OR=odds ratio; OSCC=oesophageal squamous cell carcinoma; PGI=pepsinogen I; PGII=pepsinogen II.
  2. aAdjusted for ethnicity (Non-Turkmen or Turkmen), alcohol consumption (never or ever), tobacco or opium use (none, only tobacco, only opium, or both), education level (illiterate, primary school or more), and vegetable/fruit consumption.
  3. bFor one case, PGII level was missing and just PGI level was available.
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