Table 5 Gastric atrophy defined by PGI <55 μg l⁻¹ and its association with OSCC risk under assumption of various sensitivity (se) and specificity (sp) among cases and controls

			Controls All PGII	Only PGII <5	Only PGII <11.8	Only PGII <15	Only PGII <19	Only PGII <30	Only PGII >11.8
			Se: 0.62	0.99	0.83	0.80	0.80	0.76	0.37
			Sp: 0.95	0.68	0.89	0.91	0.92	0.94	0.98
Cases	Se	Sp
All PGII	0.62	0.95	1.63	^a	6.6	3.9	3.3	2.4	0.59
Only PGII <5	0.99	0.68	^a	0.79	^a	^a	^a	^a	^a
Only PGII <11.8	0.83	0.89	0.6	a	2.5	1.5	1.3	0.9	0.2
Only PGII <15	0.80	0.91	0.8	a	3.3	1.97	1.7	1.2	0.3
Only PGII <19	0.80	0.92	0.9	^a	3.6	2.2	1.83	1.3	0.3
Only PGII <30	0.76	0.94	1.1	^a	4.6	2.8	2.3	1.65	1.66
Only PGII >11.8	0.37	0.98	4.7	^a	19.1	11.4	9.6	6.8	1.69

Abbreviations: OSCC=oesophageal squamous cell carcinoma; PGI=pepsinogen I; PGII=pepsinogen II.
ORs are adjusted for age, sex, and residence area in unconditional logistic regression model.
^aThese cells yielded negative adjusted counts, which were impossible values for true counts, thus corrected ORs could not be estimated.

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