Table 3 Summary of DLTs

From: Safety, tolerability, pharmacokinetics and pharmacodynamics of AZD8055 in advanced solid tumours and lymphoma

DLTs

CTCAE grade

Totala (%)

Increased ALT

3

3 (6)

Increased AST

3

3 (6)

Increased transaminasesb

3

2 (4)

  1. Abbreviations: ALT=alanine aminotransferase; AST=aspartate aminotransferase; CTCAE=Common Terminology Criteria for Adverse Events; DLTs, dose-limiting toxicities.
  2. aA patient may have experienced more than one DLT.
  3. bAminotransferases not specified.
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