Table 2 Risk of death from lung cancer by cumulative silica dust exposure in mg m3-years by categories, 1946–2003

From: Quantitative relationship between silica exposure and lung cancer mortality in German uranium miners, 1946–2003

Silica dust in mg m 3 -years

Mean

Person-years

# of cases

RR 95% CI unadjusted

RR 95% CI adjusted for radon

RR 95% CI adjusted for radon, arsenic

RR 95% CI adjusted for radon, arsenic with effect modifiers

0–0.5

0.1

681 780

137

1.00 Reference

1.00 Reference

1.00 Reference

1.00 Reference

0.5–2

1

394 559

283

1.12 (0.89–1.35)

1.09 (0.86–1.31)

1.08 (0.86–1.31)

0.95 (0.77–1.12)

2–5

3

274 523

356

1.26 (1.00–1.51)

1.15 (0.91–1.38)

1.13 (0.89–1.37)

0.96 (0.78–1.13)

5–10

7

238 032

430

1.38 (1.10–1.66)

1.07 (0.83–1.30)

1.05 (0.81–1.28)

0.86 (0.67–1.04)

10–20

14

264 140

936

2.45 (1.98–2.92)

1.53 (1.19–1.88)

1.47 (1.13–1.81)

1.14 (0.87–1.40)

20–30

24

108 502

664

3.76 (3.02–4.49)

2.19 (1.64–2.75)

2.05 (1.51–2.60)

1.51 (1.08–1.94)

30–56

34

23 151

189

4.71 (3.62–5.80)

2.91 (1.96–3.83)

2.79 (1.87–3.70)

2.02 (1.28–2.75)

Total

5.9

1 984 687

2995

    
  1. Abbreviations: Adj.=adjusted; CI=confidence interval; RR=relative risk.
  2. RR, baseline stratified on age in 5-year groups and individual calendar year in 58 categories.
  3. RR adj. for radon (last-but-two column), for radon and arsenic (next-to-last column) and for radon with exponential inclusion of the effect modifiers age at median exposure, time since median exposure and radon exposure rate and arsenic (last column) as continuous variables in an additive way.