Table 2 Efficacy outcome measures: OxCap vs OxFU
Regimen | |||||||
|---|---|---|---|---|---|---|---|
OxCap | OxFU | Measure of association (unadjusted) | Measure of association (adjusteda) | ||||
Outcome measure | Subgroup | Median survival (months) | HR (95% CI) | P -value | HR (95% CI) | P -value | |
OS | Arms A and C | 15.4 | 14.9 | 1.02 (0.90, 1.15) | 0.80 | 0.92 (0.78, 1.09) | 0.33 |
Arm A | 16.0 | 15.8 | 1.00 (0.84, 1.19) | 0.99 | 0.95 (0.80, 1.14) | 0.58 | |
Arm B | 15.0 | 14.9 | 1.01 (0.86, 1.20) | 0.87 | 0.94 (0.79, 1.12) | 0.51 | |
Arm C | 13.8 | 13.8 | 1.03 (0.87, 1.23) | 0.72 | 1.05 (0.88, 1.25) | 0.59 | |
PFS | Arm A | 7.4 | 8.8 | 0.93 (0.79, 1.08) | 0.34 | 0.90 (0.77, 1.06) | 0.20 |
Arm B | 7.4 | 8.5 | 0.82 (0.70, 0.96) | 0.011 | 0.79 (0.67, 0.93) | 0.004 | |
% Rate | OR (95% CI) | P -value | OR (95% CI) | P -value | |||
RR at 12 weeks | Arms A and C | 45% | 47% | 1.05 (0.85, 1.30) | 0.65 | 1.06 (0.85, 1.32) | 0.61 |
Arm B | 47% | 46% | 0.95 (0.71, 1.29) | 0.76 | 0.99 (0.72, 1.36) | 0.95 | |
ORR | Arms A and C | 51% | 54% | 1.16 (0.94, 1.44) | 0.17 | 1.18 (0.94, 1.47) | 0.15 |
Arm A | 51% | 55% | 1.16 (0.86, 1.58) | 0.33 | 1.18 (0.86, 1.62) | 0.30 | |
Arm B | 51% | 57% | 1.26 (0.93, 1.70) | 0.14 | 1.35 (0.98, 1.86) | 0.069 | |
Arm C | 50% | 54% | 1.16 (0.86, 1.57) | 0.34 | 1.16 (0.85, 1.59) | 0.36 | |
RRS | Arms A and C | 3.5% | 6.5% | 1.96 (1.21, 3.20) | 0.006 | 1.96 (1.18, 3.23) | 0.009 |
Arm A | 4.2% | 9.6% | 2.44 (1.34, 4.45) | 0.003 | 2.43 (1.30, 4.54) | 0.005 | |
Arm B | 6.4% | 7.3% | 1.17 (0.65, 2.09) | 0.61 | 1.27 (0.69, 2.33) | 0.44 | |
Arm C | 2.8% | 4.0% | 1.45 (0.65, 3.25) | 0.38 | 1.25 (0.53, 2.96) | 0.61 | |
