Table 1 Characteristics of patients with DCIS in the study
Breast-conserving surgery+radiotherapy ( N =72) | Breast-conserving surgery ( N =141) | P -value | |
|---|---|---|---|
Age mean (range) (years) | 54.4 (33.4, 81.6) | 58.1 (27, 86) | 0.04 |
Tumour size (cm) | |||
Mean (range) | 1.2 (0.09, 5.0) | 0.8 (0.02, 2.5) | <0.001 |
Comedo necrosis | |||
Yes | 48 (67%) | 87 (62%) | 0.48 |
No | 20 (28%) | 53 (37%) | |
Missing | 4 (5%) | 1 (1%) | |
Nuclear grade | |||
Low | 5 (7%) | 20 (14%) | 0.034 |
Moderate | 27 (38%) | 65 (46%) | |
High | 38 (53%) | 56 (40%) | |
Missing | 2 (2%) | ||
Multifocality | |||
Yes | 33 (46%) | 50 (35%) | 0.14 |
No | 39 (54%) | 91 (65% | |
Microinvasion | |||
Yes | 4 (6%) | 4 (3%) | 0.32 |
No | 68 (94%) | 137 (97%) | |
Size of negative margin (mm) | |||
⩽3 | 40 (56%) | 78 (61%) | 0.61 |
4–9 | 10 (14%) | 22 (17%) | |
⩾10 | 19 (27%) | 24 (19%) | |
Missing | 2 (3%) | 4 (3%) | |
Molecular markers | |||
HER2/neu+ | 19 (26.4%) | 39 (27.8%) | 0.84 |
Psoriasin continuous | 7.9 (0 ,100) | 5.2 (0, 90) | 0.27 |
Psoriasin (⩾10%) | 18 (25.0%) | 20 (14.2%) | 0.051 |
Calgranulin continuous | 5.2 (0, 75) | 11.1 (0, 100) | 0.06 |
Calgranulin (⩾10%) | 11 (15.3%) | 31 (22.0%) | 0.24 |
Ki67 continuos | 12.9 (0, 80) | 13.4 (0, 80) | 0.82 |
Ki67 (⩾10%) | 49 (68.1%) | 91 (64.5%) | 0.61 |
p53–continuous | 41.9 (0, 100) | 15.1 (0, 100) | <0.001 |
p53+(⩾10%) | 44 (61.1%) | 39 (27.7%) | <0.001 |
ER positive | 59 (81.9%) | 94 (66.7%) | 0.02 |
PR positive | 52 (72.2%) | 83 (58.9%) | 0.06 |
Cyclin D1 | 71.5 (0, 100) | 78.8 (0, 100) | 0.047 |
p21–continuous | 20.1 (0, 100) | 20.1 (0, 100) | 0.99 |
p21+(⩾10%) | 41 (57.0%) | 74 (52.4%) | 0.54 |
