Table 2 Histological predictors of local recurrence following breast-conserving surgery alone for DCIS: multivariable analysis (adjusted for age at diagnosis)
Outcome | HR (95% CI) | P -value |
|---|---|---|
Any local recurrence | ||
High nuclear grade | 2.21 (1.14, 4.29) | 0.02 |
Multifocality | 2.09 (1.09, 4.01) | 0.03 |
Tumour size | 1.01 (0.94, 1.07) | 0.89 |
Margin size | 0.96 (0.86, 1.06) | 0.40 |
Architectural subtype (solid vs other) | 0.92 (0.45, 1.86) | 0.82 |
DCIS recurrence | ||
High nuclear grade | 4.09 (1.49, 11.23) | 0.01 |
Multifocality | 2.66 (1.03, 6.88) | 0.04 |
Tumour size | 1.04 (0.95, 1.13) | 0.42 |
Margin size | 1.01 (0.87, 1.16) | 0.95 |
Architectural subtype (solid vs other) | 1.35 (0.45, 4.03) | 0.59 |
Invasive recurrence | ||
High nuclear grade | 1.27 (0.49, 3.32) | 0.62 |
Multifocality | 1.66 (0.66, 4.17) | 0.28 |
Tumour size | 0.97 (0.88, 1.07) | 0.54 |
Margin size | 0.92 (0.79, 1.07) | 0.28 |
Architectural subtype (solid vs other) | 0.66 (0.26, 1.72) | 0.40 |
