Table 3 Molecular predictors of any local recurrence
Variables | N | No of LR | Hazard ratio (95% CI) | P -value |
|---|---|---|---|---|
Univariable analysis | ||||
HER2/neu+ | 2.11 (1.21, 3.68) | 0.01 | ||
Psoriasin (⩾10%) | 0.81 (0.38, 1.72) | 0.58 | ||
Calgranulin | 1.35 (0.72, 2.54) | 0.35 | ||
Ki67 (⩾10%) | 0.91 (0.51, 1.61) | 0.75 | ||
p53+(⩾10%) | 0.89 (0.49, 1.59) | 0.68 | ||
ER positive | 0.85 (0.47, 1.53) | 0.59 | ||
PR positive | 0.94 (0.53, 1.65) | 0.82 | ||
Cyclin D1 | 1.00 (0.99, 1.01) | 0.74 | ||
p21+(⩾10%) | 1.04 (0.59, 1.81) | 0.90 | ||
Multivariable analysis (adjusted for age and XRT) | ||||
Her2/neu positive (vs other) | 58 | 22 | 2.10 (1.19, 3.69) | 0.01 |
HER2/neu+/Ki67+ (vs other) | 51 | 16 | 2.15 (1.20, 3.83) | 0.01 |
HER2/neu+/Ki67− (vs other) | 7 | 2 | 1.22 (0.29, 5.06) | 0.79 |
HER2/neu+/p53+(vs other) | 35 | 8 | 1.29 (0.64, 2.62) | 0.48 |
Ki67+/p53+ (vs other) | 63 | 12 | 1.23 (0.65, 2.33) | 0.53 |
HER2/neu+/Ki67+/p53+ (vs other) | 31 | 8 | 1.50 (0.73, 3.07) | 0.27 |
ER−/HER2/neu+/Ki67+ (vs other) | 31 | 11 | 1.52 (0.77, 2.99) | 0.23 |
