Table 4 Molecular predictors of non-invasive (DCIS) local recurrence
N | No of DCIS LR | Hazard ratio (95% CI) | P -value | |
|---|---|---|---|---|
Univariable analysis | ||||
HER2/neu+ | 2.72 (1.26, 5.88) | 0.01 | ||
Psoriasin (⩾10%) | 1.30 (0.52, 3.24) | 0.57 | ||
Calgranulin (⩾10%) | 1.47 (0.62, 3.49) | 0.39 | ||
Ki67 (⩾10%) | 1.05 (0.47, 2.35) | 0.91 | ||
p53 (⩾10%) | 0.89 (0.40, 1.99) | 0.77 | ||
ER positive | 1.14 (0.48, 2.71) | 0.77 | ||
PR positive | 0.71 (0.33, 1.53) | 0.37 | ||
Cyclin D1 (⩾10%) | 1.01 (0.99, 1.02) | 0.52 | ||
p21 (⩾10%) | 1.24 (0.57, 2.71) | 0.58 | ||
Multivariable analysis (adjusted for age and XRT) | ||||
Her2/neu+ | 58 | 13 | 2.67 (1.23, 5.79) | 0.01 |
HER2/neu+/Ki67+ (vs other) | 51 | 10 | 3.22 (1.47, 7.03) | 0.003 |
HER2/neu+/Ki67− (vs other) | 7 | 0 | Not calculable | |
HER2/neu+/p53+(vs other) | 35 | 5 | 1.54 (0.61, 3.91) | 0.36 |
Ki67+/p53+ (vs other) | 63 | 6 | 1.09 (0.44, 2.67) | 0.86 |
HER2/neu+/Ki67+/p53+ (vs other) | 31 | 5 | 1.79 (0.70, 4.57) | 0.22 |
ER−/HER2/neu+/Ki67+ (vs other) | 31 | 6 | 1.65 (0.66, 4.15) | 0.28 |
