Table 5 Molecular predictors of invasive recurrence
Univariable analysis | N | No of Inv LR | Hazard ratio (95% CI) | P -value |
|---|---|---|---|---|
HER2/neu+ | 1.58 (0.69, 3.62) | 0.28 | ||
Psoriasin (⩾10%) | 0.38 (0.09, 1.60) | 0.19 | ||
Calgranulin (⩾10%) | 1.24 (0.49, 3.12) | 0.65 | ||
Ki67 (⩾10%) | 0.79 (0.35, 1.77) | 0.56 | ||
p53 (⩾10%) | 0.88 (0.38, 2.06) | 0.77 | ||
ER positive | 0.64 (0.29, 1.45) | 0.29 | ||
PR positive | 1.30 (0.55, 3.03) | 0.55 | ||
Cyclin D1 (⩾10%) | 0.99 (0.98, 1.01) | 0.85 | ||
p21 (⩾10%) | 0.85 (0.38, 1.90) | 0.69 | ||
Multivariable analysis (adjusted for age and XRT) | ||||
HER2/neu/neu+ | 58 | 9 | 1.61 (0.70, 3.73) | 0.26 |
HER2/neu+/Ki67+ (vs other) | 51 | 6 | 1.33 (0.54, 3.28) | 0.54 |
HER2/neu+/Ki67− (vs other) | 7 | 2 | 1.22 (0.29, 5.06) | 0.79 |
HER2/neu+/p53+(vs other) | 35 | 3 | 1.04 (0.35, 3.11) | 0.94 |
Ki67+/p53+ (vs other) | 63 | 6 | 1.41 (0.57, 3.52) | 0.46 |
HER2/neu+/Ki67+/p53+ (vs other) | 31 | 3 | 1.22 (0.40, 3.69) | 0.73 |
ER−/HER2/neu+/Ki67+ (vs other) | 31 | 5 | 1.39 (0.51, 3.78) | 0.52 |
