Table 2 Risk of all-cause mortality according to use of aspirin or NSAIDs after diagnosis
Aspirin non-user, HR | Aspirin user, HR | (95% CI) | NSAID non-user, HR | NSAID user, HR | (95% CI) | |
|---|---|---|---|---|---|---|
All participants | ||||||
Deaths/number remaining alive | 4400/6925 | 958/1661 | 3914/6319 | 1444/2267 | ||
Age-adjusted HR | 1 (Ref) | 0.94 | (0.87, 1.01) | 1 (Ref) | 1.06 | (1.00, 1.13) |
Age and pre-diagnosis drug use adjusted HR | 1 (Ref) | 0.89 | (0.81, 0.98) | 1 (Ref) | 1.08 | (1.00, 1.16) |
Multivariate HRa | 1 (Ref) | 0.91 | (0.82, 1.00) | 1 (Ref) | 1.07 | (0.98, 1.15) |
Aspirin/NSAID non-users pre-diagnosis | ||||||
Deaths/number remaining alive | 3910/6231 | 192/284 | 2391/3671 | 299/308 | ||
Age-adjusted HR | 1 (Ref) | 0.99 | (0.86, 1.15) | 1 (Ref) | 1.44 | (1.27, 1.62) |
Multivariate HRa | 1 (Ref) | 0.99 | (0.84, 1.16) | 1 (Ref) | 1.46 | (1.27, 1.67) |
Aspirin/NSAID users pre-diagnosis | ||||||
Deaths/number remaining alive | 490/694 | 766/1377 | 1523/2648 | 1145/1959 | ||
Age-adjusted HR | 1 (Ref) | 0.84 | (0.75, 0.94) | 1 (Ref) | 0.97 | (0.9, 1.05) |
Multivariate HRa | 1 (Ref) | 0.86 | (0.76, 0.98) | 1 (Ref) | 0.95 | (0.87, 1.03) |
