Table 4 Risk of all-cause mortality according to use of prophylaxis-dose aspirin or NSAIDs after diagnosis
Pre-diagnosis exposure strata | Aspirin non-user, HR | Low-dose aspirin user, HR | (95% CI) | NSAID non-user, HR | Low-dose NSAID user, HR | (95% CI) |
|---|---|---|---|---|---|---|
All participants | ||||||
Deaths/number remaining alive | 4400/6925 | 772/1441 | 3914/6319 | 982/1693 | ||
Age-adjusted HR | 1 (Ref) | 0.91 | (0.84, 0.98) | 1 (Ref) | 0.94 | (0.87, 1.01) |
Age and pre-diagnosis drug use adjusted HR | 1 (Ref) | 0.86 | (0.79, 0.94) | 1 (Ref) | 0.94 | (0.87, 1.01) |
Multivariate HRa | 1 (Ref) | 0.89 | (0.8, 0.98) | 1 (Ref) | 0.94 | (0.86, 1.02) |
Aspirin/NSAID non-users pre-diagnosis | ||||||
Deaths/number remaining alive | 3910/6231 | 175/265 | 2391/3671 | 157/171 | ||
Age-adjusted HR | 1 (Ref) | 0.97 | (0.83, 1.13) | 1 (Ref) | 1.21 | (1.03, 1.42) |
Multivariate HRa | 1 (Ref) | 0.99 | (0.84, 1.16) | 1 (Ref) | 1.25 | (1.04, 1.49) |
Aspirin/NSAID users pre-diagnosis | ||||||
Deaths/number remaining alive | 490/694 | 597/1176 | 1523/2648 | 825/1522 | ||
Age-adjusted HR | 1 (Ref) | 0.81 | (0.72, 0.92) | 1 (Ref) | 0.89 | (0.81, 0.97) |
Multivariate HRa | 1 (Ref) | 0.83 | (0.73, 0.95) | 1 (Ref) | 0.88 | (0.8, 0.96) |
