Table 2 Concentration of calprotectin in pleural fluid

From: Calprotectin: a novel biomarker for the diagnosis of pleural effusion

PE origin

No. of patients

Calprotectin, ng ml −1

mean±s.d.

P- value

MPE

67

257.2±134.4

 

 Epithelial-origin neoplasias

58

238.7±112.1†

 

NSCLC

42

255.4±115.3

 

Breast cancer

6

163.6±92.1

 

SCLC

3

239.5±142.0

 

Ovarian cancer

2

183.8±128.0

 

Thymic epithelial neoplasm

2

242.9±65.8

 

Gastric cancer

2

154.1±25.1

 

Cholangiocarcinoma

1

238.6

 

 Mesothelioma

6

435.8±225.6

 

 Lymphoma

3

258.8±72.7

 
   

<0.001†††

BPE

89

2627.1±2182.1‡

 

 Tuberculous

30

2982.3±1573.0§,∥

 

 Parapneumonic

29

3517.9±2852.8**,††

 

 Miscellaneous

12

1654.8±1536.4

 

After surgery

3

763.6±357.6

 

Chylothorax

2

679.1±221.3

 

Secondary to collagen vascular diseases

2

4562.5±1621.5

 

Secondary to drug reaction

1

1169.2

 

Dressleŕs syndrome

1

1415.6

 

Uraemic pleuritis

1

572.58

 

After trauma

1

2265.5

 

Ovarian hyperstimulation syndrome

1

1660.9

 

 Paramalignant

3

1316.9±1006.6

 

 Non-neoplastic of unknown origin

15

1234.1±1164.4

 
  1. Abbreviations: BPE=benign PE; MPE=malignant PE; NSCLC=non-small cell lung cancer; PE=pleural effusion; SCLC=small cell lung cancer.
  2. †P=0.03 vs mesothelioma (Mann–Whitney U-test).
  3. ‡P<001 among BPE groups (Kruskal–Wallis test).
  4. §P<01 vs miscellaneous (Mann–Whitney U-test).
  5. ∥P<001 vs non-neoplastic of unknown origin (Mann–Whitney U-test).
  6. **P=0.02 vs miscellaneous (Mann–Whitney U-test).
  7. ††P<0.01 vs non-neoplastic of unknown origin (Mann–Whitney U-test).
  8. †††P<0.001 MPE vs BPE (Mann–Whitney U-test).
Back to article page