Figure 6

Induction of COX-2 and mutagenesis is tissue dependent. (A) Cyclooxygenase 2 was not induced in bystander liver tissues of female or male animals at a series of time points after PBIR. (B) Quantification of COX-2 protein levels in bystander liver tissues at a series of time points after irradiation. (C) Mutant frequency (MF) by Spi− assay in liver tissues of male animals at 24 h after irradiation. Error bars for quantification of COX-2 expression and relative Spi− MF in each group indicate the s.e.m. for three independent animals.