Figure 5

Connexin-26 expression in relation to postoperative development of metastasis. (A) Box plot showing the relation between Cx26 expression in the noncancerous tissues and the development of metastasis. The line within the box plot corresponds to the median value, the box length to the interquartile range, and the lines emanating from the box (whiskers) extend to the smallest and largest observations. The dotted line indicates the cutoff value of 100, which represents a high/low expression of Cx26. (B) Box plot showing the relation between Cx26 expression in the tumour tissues and the development of metastasis. (C) Kaplan–Meier biochemical recurrence-free survival curves according to the expression of Cx26 in the noncancerous prostate tissue. High expression was defined when Cx26 score was ⩾100, and a low expression was defined when the Cx26 score was >100. The cutoff value of 100 was chosen based on the differences between Cx26 expression in the noncancerous tissues of patients with and without metastasis. Statistical difference was analysed by the log-rank test (P=0.0002). Outliers are indicated by * and °.