Table 1 Sagopilone, epothilone B and paclitaxel EC50 values (nM) in TUBB3 or TUBB silenced A549, A549EpoB40 and MCF7 cells
From: Altered TUBB3 expression contributes to the epothilone response of mitotic cells
Cell line | siRNA | Sagopilone | EpothiloneB | Paclitaxel |
|---|---|---|---|---|
A549 | CTRL | 1.9±0.5 | 2.7±0.2 | 5.1±0.3 |
TUBB3 | 0.6±0.1 | 0.6±0.1 | 3.0±0.3 | |
TUBB5 | 1.1±0.1 | 1.6±0.2 | 6.8±0.7 | |
A549EpoB40 | CTRL | 10.8±0.4 | 20.8±0.7 | 44.3±4.6 |
TUBB3 | 11.5±0.4 | 25.0±0.7 | 41.2±2.1 | |
TUBB5 | 2.9±0.3 | 6.6±0.3 | 18.9±1.4 | |
MCF7 | CTRL | 0.4±0.03 | 0.3±0.01 | 4.1±1.3 |
TUBB3 | 0.1±0.1 | 0.1±0.01 | 0.6±0.1 | |
TUBB5 | 2.6±0.3 | 3.5±0.8 | 3.1±0.3 |
