Figure 3

Effects of REG Iα gene induction on resistance to anticancer drugs in gastric cancer cells. Human gastric cancer AGS cells stably transfected with pIRES2-hREG Iα (AGS-REG Iα) or pIRES2-EGFP (AGS-EGFP; control) plasmid were treated with 5-FU (A, 0.2–20 mM) or CDDP (B, 1–100 μ M) for 30 h. The percentage of viable cells was then evaluated, as described in Materials and Methods. All results are expressed as the means±s.e.m. of four samples. *P<0.001 vs AGS-EGFP at the same dose point.