Figure 5
POMC secretion and tumour growth in a xenograft model. (A) DMS 79 cells were injected s.c. into nude mice at 5 × 106 per mouse in matrigel. Tumour growth was measured daily (black line). Plasma was collected via tail nick sampling every 7 days from day 13 in order to measure circulating POMC (grey dashed line). Results are representative of five mice. (B) NCI-H526 xenografts were established using the same protocol. Plasma was collected from nude mice with no tumour (no xenograft), n=9, and NCI-H526, n=8, and DMS 79, n=5 xenografts. Tumours were excised when they reached 1000 mm3. *P<0.05; ***P<0.001.
