Figure 7
Colosphere chemosensitivity responses reflect in vivo parent colon PDX responses. (A) Effect of 5-FU on CR-IGR-007P (low responder) and CR-LRB-004P (high responder) colon cancer xenografts (in vivo) and paired colospheres viability and cytotoxicity (ex vivo graphs). (B) Effect of irinotecan on CR-IC-004M (low responder) and CR-LRB-018P (high responder) colon cancer xenografts (in vivo) and paired colospheres viability and cytotoxicity (ex vivo graphs). Data points are means±s.e.m. with 8–10 animals per group for in vivo experiments and with six-wells treated and measured per condition for ex vivo experiments. The results shown in ex vivo graphs are from one experiment taken as representative of, at least, three independent experiments.
