Table 3 Detection of rare BRAF mutations with different methods
From: Rare BRAF mutations in melanoma patients: implications for molecular testing in clinical practice
Patient ID | Pyrosequencing/Sanger sequencing | COBAS | Immunohistochemistry BRAF V600E | Localisation/organ |
|---|---|---|---|---|
1 | V600K | √ | × | Brain |
V600K | ND | ND | uk | |
2 | V600EK601del | × | ND | Primary tumour |
V600EK601del | ND | √ | Stomach | |
V600EK601del | ND | √ | Pancreas | |
3 | V600D | × | ND | Lymph node |
V600D | ND | × | Lung | |
V600D | × | ND | uk | |
4 | V600G | × | ND | Liver |
5 | V600K | √ | ND | uk |
V600K | √ | × | Lymph node | |
6 | V600K | √ | ND | uk |
7 | L597S | × | ND | uk |
L597S | ND | × | ||
L597S | ND | ND | Lymph node | |
8 | V600E2 (GAA) | Invalid | √ | Primary tumour |
V600E2 (GAA) | × | √ | Lymph node | |
9 | V600DK601del | √ | × | Skin |
V600DK601del | ND | × | Skin | |
10 | V600R | ND | × | Skin |
V600R | ND | × | Skin | |
V600R | ND | × | Skin | |
V600R | × | × | Skin | |
V600R | × | × | Skin | |
11 | V600K | √ | ND | Skin |
12 | V600K | Invalid | ND | Skin |
V600K | ND | × | Skin | |
V600K | √ | ND | Lung | |
V600K | ND | × | Skin | |
V600K | Invalid | ND | Skin | |
13 | V600K | √ | ND | Skin |
V600K | ND | √ | Skin | |
14 | V600E2 (GAA) | × | ND | Skin |
V600E2 (GAA) | × | ND | Skin |
