Table 1 Major features of the included studies

						Follow-up (months)
Study	Study location	Number of patients	Methylation rate (%)	Methylation detection method	Stage	Median	Range	Survival analysis
Barault et al, 2008	France	582	26.3	MSP	I–IV	—	—	Multivariate
Bihl et al, 2012	Switzerland	422	20.6	Pyrosequencing and MSP	I–IV	60	46–74	Multivariate
Esteller et al, 2001	Spain	86	34.9	MSP	Dukes’ A–C	68	16–89	Univariate
Ishiguro et al, 2006	Japan	88	22.7	MSP	I–IV	53.2	—	Univariate
Kim et al, 2010	Korea	131	10.7	MSP	I–IV	49	1–116	Univariate
Liang et al, 1999	China	84	28.6	MSP	Dukes’ B₂	—	60–86	Univariate
Maeda et al, 2003	Japan	90	13.3	qMSP	II–IV	54.5	—	Univariate
Shen et al, 2007	USA	182	17.0	MSP	IV	14	—	Univariate
Shima et al, 2011a,	USA	902	29.8	qMSP	I–IV	146	—	Multivariate
Veganzones-de-Castro et al, 2012	Spain	318	24.8	qMSP	Dukes’ A–D	92	75–111	Univariate
Ward et al, 2003	Australia	555	23.1	MSP	I–IV	32	1–60	Univariate

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