Figure 2
Scatter plot of −log10 P -values from the: (i) polygenic segregation model (Table 3); (ii) single gene segregation model (Table 3); (iii) logistic regression A: logistic regression estimates comparing AOCS controls against all familial cases (Table 2); and (iv) logistic regression B: logistic regression estimates comparing AOCS controls against one selected female case per family (Table 2). The dashed line represents a P-value of 0.05, the nominal significance level. SNPs are ordered by the P-values of the polygenic segregation analysis model. The segregation models generally yielded smaller P-values, indicating that these models have greater power to detect associations. 19p13 SNPs rs2363956 and rs8170 are not displayed as they are associated with ER-negative BC.
