Figure 3

(A ) Density plots of the ORS based on 22 SNPs for women with FH of BC ( n =432) and controls ( n =715). (B) ROC curve for the ability of the ORS based on 22 SNPs to discriminate between cases with FH and controls. The x-axis is 1-specificity (false-positive rate) and the y-axis is the sensitivity (true-positive rate). The dashed line represents an AUC of 0.50, indicating prediction no better than chance alone.