Table 4 Cellular protein expression in L-SCC compared with OP-SCC and CxCa, in relation to HPV16 status

	L-SCC_{HPV DNA−} (N =35)	L-SCC_{HPV16 DNA+ RNA−} (N =18)	L-SCC_{HPV16 RNA+} (N =4)	OP-SCC_{HPV DNA−} (N =93)^a	OP-SCC_{HPV16 DNA+ RNA−} (N =55)^a	OP-SCC_{HPV16 RNA+} (N =40)^a	CxCa_{HPV16 RNA+} (N =44)^b
Cellular protein expression levels	N (%)	N (%)	N (%)	(%)	(%)	(%)	(%)
p16 ^INK4a
High	0	0	3 (75)	(14)	(21)	(80)	(98)
Low	35 (100)	18 (100)	1 (25)	(86)	(79)	(20)	(2)
pRb
High	19 (54)	11 (61)	1 (25)	(89)	(82)	(15)	(5)
Low	16 (46)	7 (39)	3 (75)	(11)	(18)	(85)	(95)
CyD1
High	15 (43)	9 (50)	2 (50)	(56)	(54)	(5)	(21)^c
Low	20 (57)	9 (50)	2 (50)	(44)	(46)	(95)	(79)^c
p53
High	8 (23)	6 (33)	1 (25)	(49)	(62)	(15)	(39)
Low	27 (77)	12 (67)	3 (75)	(51)	(38)	(85)	(61)
p16_high/pRb_low	0	0	3 (75)	(5)	(8)	(80)	(95)
Other	35 (100)	18 (100)	1 (25)	(95)	(92)	(20)	(5)

This table includes only L-SCC with analysable IHC data for all four proteins (35 of 60 HPV DNA− and 22 of 25 HPV16 DNA+ L-SCC). Non-HPV16 DNA+ cases are not included for better direct comparison with HPV16 DNA+ OP-SCC and CxCa, respectively.
^aFrom Holzinger et al (2013).
^bFrom Halec et al (2012). Importantly, the protein expression in Holzinger et al (2013) and Halec et al (2012) was assessed using the same antibody references and evaluation criteria.
^cIHC results for CyD1 of CxCa series published in Halec et al (2012) are reported here for the first time. Only a small fraction, 14 of 44 HPV16 RNA+ CxCa, had enough tissue material for cyclin D1 analysis. Eleven of these 14 (79%) showed CyD1_low expression. Expression of all four proteins was similar across L-SCC_{HPV DNA−} and L-SCC_{HPV16 DNA+ RNA−} groups. Such similarity was also observed among OP-SCC_{HPV DNA−} and OP-SCC_{HPV16 DNA+ RNA−} groups (Holzinger et al, 2013).

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