Table 1 Interrelationship between clinicopathological variables

From: Immune cell infiltration as an indicator of the immune microenvironment of pancreatic cancer

Variables	Gender	Tumour size	Pathologic tumour status	Pathologic node status	Pathologic metastasis status	Histological grade	Tumour necrosis	Lymphatic invasion ^a	Venous invasion ^a	Intrapancre-atic neural invasion ^a	Nerve plexus invasion ^a	CD68 ⁺ M	CD163 ⁺ M2	CD204 ⁺ M2	%M1 ^b	CD66b ⁺ Neu	CD4 ⁺ T	CD8 ⁺ T	%Treg ^c
Age (⩾60 years/<60 years)	NS	NS	NS	NS	0.033	NS	NS	0.011	NS	0.078	NS	NS	NS	NS	NS	NS	NS	NS	NS
Gender (male/female)		NS	NS	NS	NS	NS	0.017	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS
Tumour size (<30 mm/⩾30 mm)			0.042	0.004	NS	NS	0.010	0.0002	0.002	0.034	0.030	0.075	NS	0.023	NS	NS	NS	NS	NS
Pathologic tumour status (T1+T2/T3)				NS	NS	NS	NS	0.007	0.021	NS	0.017	NS	NS	0.058	NS	NS	NS	NS	NS
Pathologic node status (N0/N1)					0.010	0.044	0.057	<0.0001	<0.0001	0.003	<0.0001	NS	NS	NS	NS	NS	NS	NS	NS
Pathologic metastasis status (M0/M1)						NS	NS	0.006	0.040	NS	NS	0.041	NS	NS	NS	NS	NS	NS	NS
Histological grade (G1/G2, G3)							0.004	0.057	<0.0001	NS	NS	NS	0.082	NS	NS	NS	0.018	NS	0.0008
Tumour necrosis (negative/positive)								NS	0.002	NS	NS	0.001	0.003	0.001	0.002	0.001	0.042	0.019	0.002
Lymphatic invasion (0, 1/2, 3)^a									<0.0001	0.0009	0.008	0.035	NS	NS	NS	NS	NS	NS	NS
Venous invasion (0, 1/2, 3)^a										0.0004	0.028	0.003	NS	0.048	NS	NS	0.067	NS	0.034
Intrapancreatic neural invasion (0, 1/2, 3)^a											<0.0001	NS	NS	NS	NS	NS	NS	NS	0.072
Nerve plexus invasion (absence/presence)^a												NS	NS	NS	NS	NS	NS	NS	NS
CD68⁺ M (low/high)													<0.0001	<0.0001	<0.0001	<0.0001	NS	NS	0.019
CD163⁺ M2 (low/high)														<0.0001	<0.0001	<0.0001	NS	NS	0.039
CD204⁺ M2 (low/high)															0.0003	0.013	NS	NS	0.006
%M1^b (low/high)																0.002	NS	0.074	0.002
CD66b⁺ Neu (low/high)																	NS	NS	0.019
CD4⁺ T (low/high)																		0.002	0.004
CD8⁺ T (low/high)																			NS
%Treg^c (low/high)

Nonsignificant (NS), P>0.10; bold value, P<0.05; underlined value, negatively correlated.
^aClassified according to the classification of pancreatic carcinoma of Japan Pancreas Society.
^bRatio of CD68⁺HLA-DR⁺ M1 to CD68⁺ M.
^cRatio of CD4⁺FOXP3⁺ Treg to CD4⁺ T.

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Table 1 Interrelationship between clinicopathological variables

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