Table 2 Univariate and multivariate analyses of tumour-infiltrating immune/inflammatory cells as prognostic factors associated with (a) overall survival and (b) disease-free survival in patients with ductal carcinoma of the pancreas

From: Immune cell infiltration as an indicator of the immune microenvironment of pancreatic cancer

 

Univariate analysis

Multivariate analysis

Variables

HR (95% CI)

P -value

HR (95% CI)

P -value

(a)

Age (â©ľ60 years/<60 years)

0.862 (0.612–1.215)

0.400

  

Gender (male/female)

1.197 (0.848–1.690)

0.306

  

Tumour size (<30 mm/⩾30 mm)

1.905 (1.257–2.887)

0.002

  

Pathologic tumour status (T1+T2/T3)

5.249 (0.733–37.6)

0.099

  

Pathologic node status (N0/N1)

2.131 (1.337–3.396)

0.002

  

Pathologic metastasis status (M0/M1)

2.572 (1.594–4.150)

0.0001

1.932 (1.169–3.192)

0.010

Histological grade (G1/G2, G3)

1.585 (1.068–2.353)

0.022

  

Tumour margin status (negative/positive)

1.526 (1.050–2.218)

0.027

  

Nerve plexus invasion (absence/presence)a

1.593 (1.114–2.278)

0.011

1.600 (1.100–2.328)

0.014

Lymphatic invasion (0, 1/2, 3)a

2.495 (1.662–3.746)

<0.0001

2.052 (1.354–3.110)

0.0007

Venous invasion (0, 1/2, 3)a

1.932 (1.355–2.755)

0.0003

  

Intrapancreatic neural invasion (0, 1/2, 3)a

1.739 (1.234–2.450)

0.002

  

CD4+Thigh/CD8+Thigh/%Treglow (yes/no)

3.501 (2.093–5.856)

<0.0001

3.206 (1.903–5.402)

<0.0001

%M1high/M2low (yes/no)

2.781 (1.877–4.119)

<0.0001

2.577 (1.726–3.846)

<0.0001

CD66b+ Neu (low/high)

1.703 (1.221–2.374)

0.002

1.486 (1.045–2.113)

0.028

(b)

Age (â©ľ60 years/<60 years)

0.864 (0.619–1.206)

0.390

  

Gender (male/female)

1.082 (0.780–1.502)

0.637

  

Tumour size (<30 mm/⩾30 mm)

1.962 (1.313–2.932)

0.001

1.631 (1.082–2.459)

0.020

Pathologic tumour status (T1+T2/T3)

4.788 (0.669–34.27)

0.119

  

Pathologic node status (N0/N1)

2.166 (1.375–3.412)

0.0009

  

Pathologic metastasis status (M0/M1)

2.585 (1.624–4.114)

<0.0001

2.046 (1.269–3.297)

0.003

Histological grade (G1/G2, G3)

1.572 (1.077–2.295)

0.019

  

Tumour margin status (negative/positive)

1.288 (0.893–1.856)

0.176

  

Nerve plexus invasion (absence/presence)a

1.510 (1.072–2.126)

0.018

  

Lymphatic invasion (0, 1/2, 3)a

1.924 (1.326–2.793)

0.0006

  

Venous invasion (0, 1/2, 3)a

2.115 (1.499–2.985)

<0.0001

1.619 (1.142–2.295)

0.007

Intrapancreatic neural invasion (0, 1/2, 3)a

1.633 (1.175–2.269)

0.004

  

CD4+Thigh/CD8+Thigh/%Treglow (yes/no)

3.123 (1.958–4.981)

<0.0001

2.667 (1.661–4.281)

<0.0001

%M1high/M2low (yes/no)

2.526 (1.743–3.660)

<0.0001

2.252 (1.545–3.284)

<0.0001

CD66b+ Neu (low/high)

1.445 (1.051–1.986)

0.024

  
  1. Abbreviations: CI=confidence interval; HR=hazard ratio. Bold value, P<0.05.
  2. aClassified according to the classification of pancreatic carcinoma of Japan Pancreas Society.
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