Figure 4

Scintigraphic images. The SPECT/CT image (A), acquired 24 h after injection of ¹¹¹In-IMP288 (185 MBq, 25 μg), pretargeted with 75 mg TF2 (1-day interval), in a 38-year-old patient (cohort 4), shows very clear tumour targeting of an axillary lymph-node metastasis, with very low concentrations of radioactivity in normal tissues. This patient had a CEA level of 17 μg l⁻¹ and the concentration of ¹¹¹In-IMP288 in the tumour was 6.3% ID kg⁻¹, with a tumour-to-normal tissue ratio of 33. Corresponding contrast-enhanced CT scan and a fused FDG-PET/CT scan are shown (B and C, respectively). The primary colon tumour (50 cm ab ano) also shows highly specific tumour targeting in the SPECT image (D), confirmed by the CT scan and FDG-PET/CT (E and F, respectively), with non-specific FDG uptake in the ascending colon.