Table 2 Dose level evaluated and encountered DLTs

From: A phase I study of the combination of ro4929097 and cediranib in patients with advanced solid tumours (PJC-004/NCI 8503)

Dose level

Drugs

Number of patients

Number of observed DLTs

DLT description

1

RO4929097 10 mg

Cediranib 20 mg

7

1

Grade 3 hypertension

2

RO4929097 20 mg

Cediranib 20 mg

7

1

Grade 4 elevation of AST

and grade 3 elevation of ALT

3

RO4929097 20 mg

Cediranib 30 mg

6

0

 
  1. Abbreviations: ALT=alanine aminotransferase; AST=aspartate aminotransferase; DLT=dose-limiting toxicity.
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